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Stefan holdenrieder dissertation

For my MD thesis I modified and evaluated an immunological assay that detected the cell death products “nucleosomes” as a new blood-based cancer biomarker. Gahan (ed.), Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring, Advances in Predictive, Preventive and Personalised Medicine 5, Springer, 2014: 309-348. As cell death processes are enhanced or suppressed during different stages of tumor development, it was assumed that they may enable stage-dependent detection of cancer disease.

Stefan holdenrieder dissertation

Stefan holdenrieder dissertation

Fröich, Kernel Methods in Chemo- and Bioinformatics, Logos Verlag Berlin, 2006 86. Zink, Janine Altmüller, Stefanie Vogt, Andreas Laner, Siegfried Uhaas, Stefanie Heilmann, Dielinde Stienen, Sandra Pasternack, Peter Propping, Markus Draaken, Holger Thiele, Franziska Degenhardt, Hartmut Engels, Andrea Hofmann, Markus Nöthen, Stefan Herms, Elke Holinski-Feder, Holger Fröich, Per Hoffmann, Stefan Aretz, Genome-wide CNV analysis in 221 unrelated patients and targeted hh-throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis, Int. Oliver Kaut, Ina Schmitt, Jörg Tost, Florence Busato, Yi Liu, Per Hofmann, Stephanie H. Beerenwinkel, NEMix: Single-cell Nested Effects Models for Probabilistic Pathway Stimulation, PLo S Comp. Kaminski, Patrik Foerch, Alexander Pfeifer, Different micro RNA profiles in chronic epilepsy versus acute seizure mouse models, J Mol Neuroscience, 55(2):466-79, 2015 (awared with Neuroallianz Silver medal).

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  • Our early studies showed that the amount of nucleosomes is increased in sera of patients with many cancer types, among them also in colorectal cancer, when compared with healthy individuals. Unfortunately, also patients with benn organ-related diseases, such as inflammations or non-tumor lesions, showed elevated levels limiting the diagnostic value of this parameter if taken as sole criterion.


    Stefan holdenrieder dissertation

    Stefan holdenrieder dissertation

    Stefan holdenrieder dissertation

    Ransmayr, Gerhard ; Oewein, Christian ; Will Edgar; Fröich Holger; Pesch Hanna; Lauterbach, Thomas ; Timmermann, Lars; Bauer, Lars; Kassubek, Jan, Patients' perception of Parkinson's disease-associated pain following initiation of rototine: a multicenter non-interventional study, Postgraduate Medicine, 129(1):46-54, 2016. Anita Kretschmann; Khalid Abnaof; Marijke van Rikxoort; Kirsten Ridder; Holger Fröich; Benedicte Danis; Rafal Kaminski; Patrik Foerch; Christian Elger; Frank Weinsberg; Alexander Pfeifer, Changes in serum mi RNAs following generalized convulsive seizures in human mesial temporal lobe epilepsy, Biochemical and Biophysical Research Communications, 481(1-2): 13 - 18, 2016 84. Anita Kretschmann, Benedicte Danis, Lidija Andonovic, Khalid Abnaof, Marijke van Rikxoort, Franziska Siegel, Manuela Mazzuferi, Patrice Godard, Etienne Hanon, Holger Fröich, Rafal M. Frenzel, Alexander Shimabukuro-Vornhagen, Sebastian Theurich, Julia Claasen, Christof Scheid, Michael von Bergwelt Baildon, Holger Fröich, Clemens M. Chemnitz, CD4 T-cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation, Annals of Hematolgy, 94(1):129-37, 2015. Publications Orinal papers 102 (first / senior 52) Reviews 54 (first / senior 42) Hirsch factor 24 Impact factors 333 (accumulated) 10 Relevant Publications Sinning JM, Wollert K, Sedaghat A, Widera C, Radermacher MC, Descoups C, Hammerstingl C, Weber M, Stundl A, Ghanem MC, Widder J, Vasa-Nicotera M, Mellert F, Schiller W, Bauersachs J, Zur B, Holdenrieder S, Welz A, Grube E, Pencina MJ, Nicken G, Werner N, Kempf T. Circulating nucleosomes and immunogenic cell death markers HMGB1, s RAGE and DNAse in patients with advanced pancreatic cancer undergoing chemotherapy. Gezer U, Üstek D, Yörüker EE, Cakiris A, Abaci N, Leszinski G, Dalay N, Holdenrieder S.

    Stefan holdenrieder dissertation

    Today much more is known about the tumor-specific changes of the histone and DNA component – and ques are available to detect these modifications not only at the tumor site but also in blood circulation. DOING MY BOYFRIENDS HOMEWORK There are many reasons why a cookie could not be set correctly.


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